Posts Tagged ‘profilin’

Spring and April tree pollen hay fever

Friday, April 1st, 2011

Spring has suddenly broken through the icy winter and the trees are covered in blossom this April. But this is a time of discomfort and suffering for those tree pollen allergic hay fever sufferers who will experience itching, sneezing, watering nose and irritatingly painful eyes. Silver birch pollen will be pouring from dangling catkins suspended from dormant trees coming back to life again after the long cold winter. Silver Birch pollen contains a particulary potent allergy provoking substance called Bet V 1 otherwise known as Profilin, which is curiously also contained in fresh apples, pears and stone fruit such as peaches, nectarines, cherries and plums. In addition, Profilin is found in hazelnuts and walnuts as well as vegetables such as celery, carrot, potato and tomato.  Fortunately most  afflicted will only experience itching of the mouth, palate and throat if they eat these foods in the raw form. Cooking these foods damages the Profilins and makes them less allergy provoking. These pollen-food cross reactions are usually irritating but rarely ever lead to more serious allergic reaction such as anaphylaxis and  will respond promptly to antihistamine medication such as cetiriizine, loratadine and fexofenadine.

Visit our webpage on hay fever and oral allergies for more information

www.allergy-clinic.co.uk/airway-allergy/hayfever

http://www.allergy-clinic.co.uk/airway-allergy/oral-allergy-syndrome

New technologies in allergy testing

Friday, December 4th, 2009

Even if allergic to the same food, not all people react to the same protein in the food. There a number of potential allergy provoking proteins found in each food.

Cow’s milk allergy sufferers may react to one of five different casein or whey proteins in milk. Hence most casein allergic children react to cheese and goats milk while whey allergic children seem to tolerate these products. Heating of milk lowers the allergy potential of the whey components. This explains why whey allergic children seem to tolerate boiled or UHT long-life cow’s milk.

The five principal allergenic proteins in cow’s milk have now been identified as Bos d 4 (alpha-lactalbumin) and Bos d 5 (beta-lactglobulin) in whey, as well as Bos d 6 (Bovine serum albumin), Bos d 8 (Casein) and Bos d lactoferrin (Bovine lactoferrin)

While in Hens’ egg white, there are four different allergenic proteins. These are Gal d 1 (Ovomucoid), Gal d 2 (Ovalbumin), Gal d 3 (Conalbumin) and Gal d 4 (Lysozyme).  One of these could set off an egg allergic reaction in a sensitised individual.

In Peanut we find 9 different Ara h allergens and in Latex there are 13 different Hev b allergens, all capable of triggering a peanut or latex allergic reaction. The Latex Hev b 8 allergen, also called a Profilin is similar to the allergy provoking Profilin found in apple, banana and many other fruits.

This may seem very complicated, but a new range of allergy tests for these specific components are now available.  The tests are called recombinant allergen components and confirm to which protein in a food the individual will react.  Certain allergy provoking proteins such as Profilin, PR-10 proteins, Tropomyosin and Lipid Transfer Protein (LTP) can occur in unrelated food such as Hazelnut and Apple or Latex and Avocado. For example an unsuspecting Latex allergy sufferer may have an acute allergic reaction when eating Avocado, Banana, Kiwi or Chestnut for the first time.

Once the specific allergen is identified on allergy testing, the person can be advised which other foods may cause an adverse allergic reaction

Ref: Steinman H, Native & recombinant allergen components. Phadia AB 2008, ISBN 91-970475-6-2