Autoimmune Progesterone Dermatitis is a rare condition related to a hypersensitivity to endogenous overproduction or sensitivity to progesterone the sex hormone in fertile (ovulating) and pregnant women. Those affected develop dermatitis during the luteal phase of their menstrual cycle (7 days before the period commences). The skin lesions can include eczema, folliculitis, hives, Urticaria, small blistering lesions on the skin and mouth and even target like lesions. Confirmation involves a positive intradermal skin test when injected with a small amount of progesterone hormone.
Treatment involves avoiding progesterone containing contraceptives, and suppressing ovulation with Danazole before the period or using Tamoxiifen.